Genetic regulation of growth in height and weight from 3 to 12 years of age: a longitudinal study of Dutch twin children.

نویسندگان

  • Karri Silventoinen
  • Meike Bartels
  • Daniëlle Posthuma
  • G Frederiek Estourgie-van Burk
  • Gonneke Willemsen
  • Toos C E M van Beijsterveldt
  • Dorret I Boomsma
چکیده

Human growth is a complex and poorly understood process. We studied the effect of genetic and environmental factors on height and body mass index (BMI, kg/m(2)) based on maternal reports at 3, 4, 5, 7, 10 and 12 years of age in a large longitudinal cohort of Dutch twins (7755 complete twin pairs at age 3). Several multivariate variance component models for twins were fitted to the data using the Mx statistical package. The first-born twin was taller until age 10 and heavier until age 12 than the second-born co-twin. Heritability estimates were high for height (a(2) = .58-.91) and BMI (a(2) = .31-.82), but common and unshared environmental factors were also important. The phenotypic correlations across the ages for height and BMI were mainly explained by correlated additive genetic factors (r(a) = .77-.96 for height and .43-.92 for BMI), but common (r(c) = .40-.84 and .09-.78, respectively) and specific environmental correlations (r(e) = .50-.81 and .42-.80, respectively) were also significant. Additive genetic factors decreased with increasing age difference for both height and BMI. However, the full Cholesky model, which does not make any assumptions regarding the underlying genetic structure, had the best fit. High genetic correlations across the ages, especially for height, may help further molecular genetic studies of human growth. Environmental factors affecting height and BMI during growth period are also important, and further studies are needed to identify these factors and test whether they interact with genetic factors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Longitudinal Growth Study from Birth to Maturity for Weight, Height and Head Circumference of Normal Iranian Children Compared with Western Norms: A Standard for Growth of Iranian Children

Background: At the present there is no growth reference for Iranian children, and cross-sectional studies indicate that Iranian children grow at a lower percentile curve than Western children.Aim: The present longitudinal study was undertaken: 1. To establish a growth standard for Iranian children and, 2. To compare their growth with Western norms. Methods: Weight, length, height, and head circ...

متن کامل

تعیین نورموگرام رشد دانش آموزان دختر 11-14 ساله شهر بیرجند در سال 1383 و مقایسه آن با مقادیر مرجع مرکز آمارهای بهداشتی

Background and Aim: Measurement of weight and height is very important source of information in evaluation of growth, nutrition and health of children and adolescence. Since, the growth is affected by genetic, racial, geographical and environmental factors, the growth charts differ from one population to another. The aim of this study was Measurement of weight and height of girls’ students in ...

متن کامل

Length and weight growth trends for children less than two years old in Zanjan, Iran: Longitudinal modeling

Background: Growth failure in children less than five years old can lead to the serious complications such as increased mortality, learning difficulties or physical disability. The aim of this study was to investigate the non-organic factors affecting the growth trend in less than two years children living in Zanjan, Iran.   Methods: This longitudinal study was conducted on a sample of ...

متن کامل

The growth assessment of very low birth weight infant at corrected two years old

Background: The aim of this study was to determine the growth status of very low birth infant at corrected age of two years. Methods: This cross-sectional study was performed on all babies with birth weight ≤1500 gr without any congenital anomalies, genetic disturbance and chronic disease (e.g. cardiopulmonary insufficiency, cholestasis, malabsorption). They were called at corrected age 2 year...

متن کامل

بررسی رشد کودکان از بدو تولد تا دو سالگی در مناطق روستایی شهرستان بابل در سال 1377

Background and purpose: The evaluation of growth monitoring in children is one of the important sources of information to detect malnutrition. The objective of this study was to determine the trend of infant growth from birth to two years in rural communities of Babol and to compare it with NÇHS standard. Materials and methods: This study was based on the existing data in growth monitoring...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Twin research and human genetics : the official journal of the International Society for Twin Studies

دوره 10 2  شماره 

صفحات  -

تاریخ انتشار 2007